ROS1 targeted therapy has revolutionized the treatment of ROS1-positive (ROS1+) cancers, offering patients hope and extended survival through tyrosine kinase inhibitors (TKIs). While these therapies are highly effective in controlling cancer progression, they also come with a range of side effects. One that can be particularly frustrating for patients is weight gain. Managing weight gain is crucial not only for comfort and well-being but also for maintaining overall health throughout the treatment process. In this article, we'll explore why weight gain occurs, how to manage it, and when to consult your healthcare team.
Why weight gain happens
Weight gain is a known side effect of TKIs used in ROS1+ cancer treatment. The reasons for this are multifaceted. First, TKIs can cause fluid retention, leading to a rapid increase in weight, especially in the early stages of treatment. This swelling, or edema, often occurs in the hands, feet, and lower legs, contributing to the sensation of being heavier or bloated.
In addition to fluid retention, other factors like changes in metabolism, reduced physical activity due to cancer-related fatigue or side effects of cancer treatment, and alterations in appetite can also contribute to weight gain. Some patients find themselves eating more as a way to cope with the emotional and physical toll of treatment, further complicating weight management.
Managing weight gain: Practical tips
While weight gain during ROS1 targeted therapy can feel overwhelming, there are strategies to help manage it. Addressing fluid retention, diet, and physical activity can make a significant difference.
1. Addressing fluid retention
If fluid retention is a major contributor to your weight gain, there are a few ways to manage it:
Stay hydrated: It might seem counterintuitive, but staying well-hydrated helps your body eliminate excess fluid. Aim for 8-10 glasses of water a day unless your healthcare provider advises otherwise.
Limit sodium intake: Salt contributes to water retention. Reducing your sodium intake by avoiding processed foods and opting for fresh, whole foods can help minimize swelling.
Compression garments: Wearing compression socks or sleeves can help reduce swelling in your legs and arms, making you feel more comfortable.
2. Watch Your Diet
Monitoring your diet can also help manage weight gain. While it's important to maintain a healthy intake of nutrients to support your body's fight against cancer, being mindful of what you eat can help keep your weight in check:
Focus on nutrient-dense foods: Prioritize fruits, vegetables, lean proteins, and whole grains to get the nutrients you need without excessive calories. As noted above, foods that are processed and high in sodium affect weight and fluid retention. They also lack essential nutrients.
Control portions: Eating smaller, more frequent meals can help manage appetite without overeating.
Limit comfort foods: It’s natural to seek comfort through food, but try to limit high-calorie comfort foods, such as sweets and processed snacks, that can contribute to weight gain.
3. Stay active
Physical activity plays a crucial role in managing weight gain. However, the fatigue and physical limitations that come with cancer treatment can make it difficult to stay active. Here are some low-impact activities to consider:
Walking: Even short daily walks can burn calories, improve circulation, and lift your mood.
Strength training: Light resistance exercises can maintain muscle mass, which can be lost during cancer treatment, while also boosting metabolism.
Stretching and yoga: These gentle activities can improve flexibility, reduce stress, and contribute to overall well-being without putting too much strain on the body.
Talk to your healthcare team
If you’re struggling to manage weight gain during ROS1 targeted therapy, it’s essential to talk to your healthcare provider. They can assess the cause of your weight gain—whether it’s fluid retention, metabolic changes, or other factors—and provide guidance on how to manage it. In some cases, adjustments to your medication dosage or adding diuretics (to help eliminate excess fluid) may be recommended.
Additionally, your healthcare team can refer you to a nutritionist or dietitian who specializes in cancer care. They can create a meal plan tailored to your needs, ensuring you get the necessary nutrients without contributing to weight gain.
Emotional impact of weight gain
It’s important to acknowledge the emotional toll that weight gain can have during cancer treatment. For many patients, gaining weight adds another layer of stress and frustration during an already difficult time. It can affect self-esteem, confidence, and overall quality of life.
If you’re feeling emotionally overwhelmed by weight changes, consider speaking with a counselor or connecting with The ROS1ders. Sometimes, just talking about your experiences with others going through the same thing can alleviate some of the emotional burden.
Weight gain is a common side effect of ROS1 targeted therapy but with the right strategies, it can be managed effectively. By addressing fluid retention, making mindful dietary choices, staying active, and communicating with your healthcare team, you can better control your weight during treatment. Remember, every patient’s experience is unique, so finding the approach that works best for you is key.
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